摘要
目的:观察唑来膦酸联合来曲唑治疗绝经后乳腺癌骨转移的疗效及不良反应。方法:40例绝经后乳腺癌骨转移患者给予唑来膦酸(4mg加入生理盐水100ml静滴)和来曲唑片(2.5mg/d口服)治疗,28天为一周期,治疗3个周期评价疗效并记录不良反应。结果:40例患者均可评价疗效。治疗后疼痛缓解、骨转移病灶疗效、活动能力改善的有效率分别为90.00%、52.5%和77.50%,治疗后患者生活质量明显提高,未出现严重不良反应。结论:唑来膦酸联合来曲唑治疗绝经后乳腺癌骨转移有较好的治疗作用,不良反应轻,患者易于耐受。
To observe the therapeutic：effects andadverse reactions of zoledronic acid combined letrozole in treatment of postmenopausal breast cancer patients with b0ny metastasis.Methods：40 postmenopausal breast cancer patients with bony metastasis：were：treated with zoledronic： acid （4mg＋100ml physiological saline, iv） and letrozole （2.5mg/d, oral）. The therapeutic effects and adverse reactions were evaluated after 3 treating cycles （28-day as 1 cycle）.Results：All the 40 patients could be：evaluated therapeutic effects. After treatment, the effective rate of easement of pain, bony metastasis lesion and improvement of locomotor.activity were respectively 90.00%, 52.5% and 77.50%. After treatment, the fife quality of patients improved obviously：and no serious adverse reactions were observed. Conelusions：Zoledronie acid combined letrozole for treating postmenopausal breast cancer patients with bony metastasis has better effects and light adverse reactions, and patients easy tO tolerance.
出处
《承德医学院学报》
2012年第1期25-27,共3页
Journal of Chengde Medical University
关键词
唑来膦酸
来曲唑
绝经后乳腺癌
骨转移
Zoledronic acid
LetrozoieilPostmenopausalbreast cancer
Bony metastasis
