神经干细胞迁移的研究进展

Directed Migration of Neural Stem Cells

神经干细胞的定向迁移是胚胎神经系统发育的先决条件,同时在成体组织的许多生理、病理过程中也起着重要作用;研究发现,许多神经退行性疾病都与神经干细胞迁移的缺陷相关。近年来,越来越多的证据表明,无论是内源性的还是移植的神经干细胞都有向大脑损伤部位迁移的特性,显示出神经干细胞用于神经再生及损伤修复治疗的潜能。该文着重在神经干细胞的基本特性以及神经干细胞定向迁移的细胞与分子机制研究等方面进行了综述。

A precise migration of neural stem/progenitor cells（NSCs） is prerequisite during development for the formation of the nervous system and plays a pivotal role in a variety of both physiological and pathological events in adult.Many neurodegenerative diseases are closely related to the deficient migration of NSCs.Increasing studies have demonstrated that NSCs,either endogenous or transplanted,are highly motile and display a unique tropism for areas of pathology in the adult brain.This phenomenon reveals a therapeutic potential of NSCs for the neural regeneration and nerve repair after injury.In this review,we focus on the knowledge of the discovery and the location of NSCs,and the studies on the cellular and molecular mechanisms that govern the directed migration of these cells.