代谢综合征患者血清Apelin水平增高

Increasing of serum apelin level in patients with metabolic syndrome

探讨代谢综合征（Ms）患者血清Apelin的变化。用ELISA法测定血清Apelin。MS组Apelin明显升高（P〈0．01），2型糖尿病MS组Apelin明显高于糖调节受损MS组和超重或肥胖者[（475．8±37．3对451．5±54．3及430．3±52．1）ng／L，P〈0．01]。多元逐步回归分析显示，胰岛素抵抗、体重指数和总胆固醇是Apelin独立相关因素。MS多种代谢组分异常与Apelin升高密切相关，可能是胰岛素抵抗加重所致。

The changes of serum apelin in patients with metabolic syndrome were investigated. The level of fasting serum apelin was determined by ELISA assay. The level of serum apelin was raised obviously in patients with metabolic syndrome（MS）. Moreover, the level of serum apelin in patients with type 2 diabetes mellitus was higher than those in cases of MS with impaired glucose regulation and the group of subjects with overweight/obesity [ （475.8 ＋ 37.3 vs 451.5 ~54. 3 and 430. 3 ~52. 1 ） ng/L, P〈0. O1 ]. In a multiple step-wise regression analysis, In homeostasis model assessment of insulin resistance（ HOMA-IR）, body mass index, and total cholesterol were independent factors of apelin. The increased serum apelin was closely related to metabolic abnormalities in metabolic syndrome. The increased insulin resistance might cause the raised level of serum apelin in patients with MS.