血清CXC趋化因子配体10水平与Graves病的关系

The relationship between serum CXC chemoldne ligand-lO level and Graves＇ disease

检测不同临床阶段Graves病（GD）患者和正常对照者血清CXC趋化因子配体10（CXCLIO），发现GD未治疗组及复发组高于GD缓解组及正常对照组（P〈0．01），且前2组间差异也有统计学意义（P〈0．01）．后2组间差异无统计学意义（P〉0．05）。血清CXCL10与FT3、FT4水平呈正相关，与TSH水平呈负相关（均P〈O．01）。多元线性回归分析显示：CXCL10是影响FT3、FT4、TSH水平的危险因素（P〈0．01）。

The serum level of CXCL10 was determined in both patients with Graves＇ disease （GD） and normal control subjects. Serum CXCL10 levels in untreated and relapsed GD groups were higher compared with the remission group and control group（ P〈0.01 ）. A significant difference was observed between the former two GD groups （ P〈0.01 ）, but no difference was found between latter two groups（ P〉0. 05 ）. Serum CXCLIO levels were positively correlated with FT3 and FT4, and negatively correlated with TSH by multiple linear regression analysis（ P〈0. 01 ）.