期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

二甲双胍对高脂诱导胰岛素抵抗大鼠vaspinmRNA表达水平的影响 被引量：3

The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet
原文传递
导出
摘要 采用高脂喂养并利用清醒状态下正糖一高胰岛素钳夹技术评估胰岛素抵抗大鼠模型。胰岛素抵抗大鼠脂肪组织vaspin mRNA表达量明显低于对照组（P〈0．05），二甲双胍治疗后表达升高（P〈0．05），提示二甲双胍在改善大鼠胰岛素抵抗状态的同时能上调胰岛素抵抗大鼠内脏脂肪组织vaspinmRNA的表达。 High-fat diet-induced＇insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique. Compared with the control group, the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet （P〈0. 05 ）, which was increased by metformin （P〈0. 05 ）. These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression.
作者 刘慧蔷 裴丽娜 都健 杨晶 张盈妍
机构地区 中国医科大学附属第一医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2012年第3期231-234,共4页 Chinese Journal of Endocrinology and Metabolism
基金 辽宁省科学技术计划项目（2009225029） 辽宁省教育厅科技项目（L2010597）
关键词 胰岛素抵抗 VASPIN 二甲双胍 正常血糖-高胰岛素钳夹技术 大鼠 Insulin resistance Vaspin Mefformin Euglycemic-hyperinsulinemic clamp Rats
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献4

二级参考文献23

  • 1都健,赵晓娟,刘国良.胰岛素抵抗大鼠内皮依赖性血管舒张功能研究[J].中华内分泌代谢杂志,2003,19(4):313-316. 被引量：23
  • 2Hickenbottom SL, Grotta JC, Strong R, et al. Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in rats[ J]. Stroke, 1999, 30( 11 ) :2472 - 2478.
  • 3Nakamori Y, Emoto M, Fukuda N, et al. Myosin motor Myolc and its receptor NEMO/IKK-7 promote TNF-α induced serine307 phosphorylation of IRS- 1[J].J Cell Biol, 2006, 173 (5) : 655 - 671.
  • 4Boden G, She P, Mozzoli M, et al. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver[J]. Diabetes, 2005, 54(12):3458- 3465.
  • 5Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF- kappaB[J]. Nat Med, 2005, 11 (2) : 183 - 190.
  • 6Tamura Y, Ogihara T, Uchida T, et al. Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice [J]. Diabetologia, 2007, 50( 1 ) : 131 - 141.
  • 7Ajuwon KM, Spurlock ME. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNF-alpha expression in 3T3-L1 adipocytes[J]. J Nutr, 2005, 135(8):1841 - 1846.
  • 8Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance [ J]. J Clin Invest, 2006, 116(11) :3015 - 3025
  • 9Boden G.Endoplasmic reticulum stress:another link between obesity and insulin resistance/inflammation? Diabetes,2009,58:693 -700.
  • 10Nakatani Y,Kaneto H,Kawamori D,et al.Involvement of endoplasmic reticulum stress in insulin resistance and diabetes.J Biol Chem,2005,280:847-851.

共引文献34

同被引文献26

  • 1杨丽,陈东风.非酒精性脂肪性肝病的治疗现状[J].重庆医学,2007,36(8):715-718. 被引量：9
  • 2Luef G, Rauchenzauner M, Waldmann M, et al. Non-alcoholic fatty liver disease(NAFLD), insulin resistance and lipid profile in antiepi- leptic drug treatment[J]. Epilepsy Res, 2009, 86(1): 42-47.
  • 3Gastaldelli A, Kozakova M, H jlund K, et al. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population[J]. Hepatology, 2009, 49(5): 1537-1544.
  • 4Uzun MA, Koksal N, Aktas S, et al. The effect of ursodeoxycholic acid on liver regeneration after partial hepatectomy in rats with non-alcoholic fatty liver disease[J]. Hepatol Res, 2009, 39(8): 814- 821.
  • 5De Hines J. Congestive heart failure and diabetes mellitus:an intricated relationship. Rev Med Liege 2007 ;62 : 112 - 117.
  • 6Adachi H, Oguri M, et al. Effect of insulin sensitivity on se- verity of heart failure. Diabetes Res Clin Pract 2007 ; Apr 26 [ Epud a- head of print].
  • 7Mckee P, Castell W, Mcnamara P, et al. The natural history of congestive heart failure, the Framingham study. N Eng Med 1971 ; 285 (26) : 14444.
  • 8Anker SD, Ponikowski P, Vamey S, et al. Wasting as inde- pendent risk factor for mortality in chronic heart failure. Lancet 1997 ; 349,1050.
  • 9Haffner SM, Gonzalez C, Miettinen H, et al. A prospective a- nalysis of the HOMA model. The Mexico City Diabetes Study. Diabe- tes Care 1996;19:1138.
  • 10Wallace TM, Mattews DR. The assessment of insulin resist- ance in man. Diabet Med 2002 ; 19:527 - 534.

引证文献3

二级引证文献7

中华内分泌代谢杂志
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部