摘要
探讨梓醇对糖尿病大鼠肾脏是否具有保护作用及其可能机制。RT-PCR、免疫组化和Western印迹法检测糖尿病大鼠肾脏组织中胰岛素样生长因子I和蛋白激酶B表达，结果发现两者mRNA及蛋白表达均上调，梓醇可下调其表达并减轻肾脏损伤。
This study was designed to explone whether catalpol exerts a protective effects on kidney of diabetic rats and its possible mechanism. Insulin-like growth factor- I （IGF- I ） and protein kinase B（PKB/Akt） mRNA and protein expression in kidney of diabetic rats were up-regulated as results of assessments by RT-PCR, immunohistochemistry and Western blot. Catalpol could partially reduce IGF- I and Akt expressions in kidney of diabetic rats, and thus alleviate the damage of kidney.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2012年第3期237-238,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
梓醇
糖尿病肾病
胰岛素样生长因子I
蛋白激酶B
Catalpol
Diabetic nephropathy
Insulin-like growth factor - I
Protein kinase B
