湿法制粒中软材物性参数的表征方法研究

Research of evaluation of physical characters of damp mass during wet granulation

目的建立中药提取物软材评价方法。方法本实验初步建立了中药提取物湿法制粒软材黏性的表征方法,通过考察软材黏性和颗粒得率的相关性,得到了湿法制粒过程中软材黏性的"适宜区域",并绘制了黏度值-润湿剂用量-乙醇体积分数三者相关性三维图。结果不同的中药提取物会呈现出不同的"适宜性区域"。结论通过比较"适宜区域"在底面投影面积的大小来比较湿法制粒在各中药提取物中的适宜性。

AIM To evaluate the damp mass preparation of Chinese herbs extracts. METHODS Comparing between the damp mass viscidity and the granulation yield, the ＂viscidity fitting zone＂ can be found and the 3-di- mension （ 3 D） graphics about viscidity-wetting agent-C （EtOH） be drown. RESULTS The ＂viscidity fitting zone＂ of different extracts have the different undersurface projected areas in the 3-dimension （3D）graphics. CONCLU- SION The suitable characters would be compared by the undersurface projected area of ＂fitting zone＂.