甘草黄酮胶囊成型工艺的研究

Study on the molding process of Licorice Flavonoids Capsules

目的确定甘草黄酮胶囊剂成型工艺条件。方法以吸湿率、休止角、堆密度、成型性为筛选指标,确定甘草黄酮胶囊的处方组成;以制剂的外观、性状、崩解时限、含量为评价指标,确定工艺路线。结果甘草黄酮∶预胶化淀粉∶微晶纤维素∶乳糖(27∶4∶7∶2)为最佳处方组成。结论通过质量检测及稳定性实验,证明所确定的工艺路线可行。

Objective To determine the conditions of molding of Licorice Flavonoids Capsules. Methods Moisture absorption rate,an- gle of repose,bulk density,and formability were used as index to determine the composition of Licorice Flavonoids Capsules;the appearance,properties, disintegration time, and content of the preparation were used as evaluation indicators to determine the process route. Results Licorice flavonoids ： pregelatinized starch ： microcrystalline cellulose ： lactose （27 ： 4： 7 ： 2） was selected as the best prescription form. Conclusions Through quality and stability tests,the determined process is proven to be a feasible route.