摘要
目的探讨黄酮碳苷类化合物抗炎活性的构效关系。方法从短瓣金莲花中分离制备12个黄酮碳苷系列化合物,进行抗炎活性评价。结果黄酮碳苷化合物的糖基、酚羟基的取代位置、数量等影响黄酮碳苷的抗炎活性。结论黄酮碳苷类化合物的抗炎活性具有一定的构效关系。
Objective To study the QSAR of C-glycosyflavones on anti-inflammatory activities. Methods 12 C-glycosyflavones were prepared from the extract of Trollius ledebouri Reichb and their anti-inflammatory activities were evaluated by TPA-induced mouse ear edema（in vivo）. Results The main factors were sugar moiety and OH affecting the anti-inflammatory activities of C-glycosyflavones. Conclusion The QSAR of C-glycosyflavones were identified.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2012年第3期632-633,共2页
Lishizhen Medicine and Materia Medica Research
基金
中国人民解放军南京军区"122"工程培养项目
中国人民解放军南京军区"十一.五"基金项目(No.06MA45)
安徽省卫生厅临床科研项目(No.2010C097)
关键词
黄酮碳苷类化合物
构效关系
抗炎活性
C-glycosyflavones
Quantitative structure-activity relationship
Anti-inflammatory activity
