摘要
目的研究一种可促进普罗布考口服淋巴吸收的胶束给药系统。方法使用甲氧基聚乙二醇磷脂酰乙醇胺(mPEG-DSPE)作为载体材料,制备载普罗布考胶束给药系统并进行优化,并通过清醒大鼠淋巴插管模型评价其提高药物口服淋巴转运的作用。结果经处方优化以后,以mPF^DSPE作为载体材料制备的载普罗布考胶束的包封率>90%。清醒大鼠淋巴插管模型考察结果表明,载药胶束8 h内的淋巴转运药物累积量约为混悬组的3倍。结论 mPEC-DSPE胶束给药系统可显著提高普罗布考的淋巴转运量。
AIM To develop a drug-loaded micelle formulation which could enhance the oral lymphatic absorption of probucol. METHODS mPEG-DSPE was chosen to prepare the micelle by film formation method. Conscious rat model was chosen for the in vivo evaluation of the micelle. RESULTS Encapsulated efficiency of probucol in the miceUe was higher than 90%. Probucol transported by lymph in 8 h after administration in drug-loaded micelle group was three times than that from probucol suspension group. CONCLUSION mPEG-DSPE based miceUe could significantly improve the lymphatic absorption of probucol.
出处
《中国临床药学杂志》
CAS
2012年第2期83-87,共5页
Chinese Journal of Clinical Pharmacy
关键词
普罗布考
胶束
口服淋巴吸收
probucol
micelle
oral lymphatic absorption
