联二萘酚类磷酸吡哆醛模拟酶的合成与应用研究进展

Progress in Synthesis and Application of Binaphthol Type Pyridoxal Phosphate Mimic Enzyme

模拟酶化合物的合成与应用研究具有重要的理论和实际意义。近年来研究的一些联二萘酚类磷酸吡哆醛模拟酶具有氨基酸构型转换的功能,并可用于手性氨基醇的对映选择性识别。本文简要介绍了该类化合物的合成方法,综述了近年来联二萘酚类磷酸吡哆醛模拟酶在手性氨基酸构型转换、手性氨基醇对映选择性识别以及萃取拆分等方面的应用。

Study on synthesis and application of artificial enzyme has important theoretical and applicable significance.Some recently studied binaphthol type pyridoxal phosphate mimic enzymes bearing the function of amino acid chiral conversion can be applied to enantioselective recognition of chiral 1,2-amino alcohols.Their synthesis and the application in chiral conversion of amino acids,enantioselective recognition of chiral 1,2-amino alcohols and extractive separation of amino acids as well as 1,2-amino alcohols were reviewed in this paper.