PPARs调控巨噬细胞的活化与功能

Control of macrophage activation and function by PPARs

巨噬细胞是先天性防御病原体的关键组分,它参与炎症的发生和消退,同时也参与了组织的修复。巨噬细胞的多种功能通过不同的活化状态完成,即从经典活化状态到替代性活化状态,再到失活状态。巨噬细胞活化的失调与代谢、炎症和免疫病变有关,调节蛋白控制巨噬细胞的活化可作为新的治疗靶点。主要综述过氧化物酶体增殖物激活受体(PPARs)调控巨噬细胞活化的作用。

Macrophage,a key component of the innate defense against pathogens,participates in the initiation and resolution of inflammation,and in the maintenance of tissues.These diverse functions of macrophages are executed via distinct activation states,ranging from classical to alternative to deactivation.The dysregulation of macrophage activation is pathogenically linked to various metabolic,inflammatory and immune disorders.Regulatory proteins controlling macrophage activation have emerged as important new therapeutic targets.Here,the mechanisms by which peroxisome proliferator-activated receptors（PPARs） transcriptionally regulate macrophage activation in disease states are reviewed.