重组人脑钠肽对扩张型心肌病及心肌梗死所致急性心力衰竭的治疗效果

Efficacy of lyophilized recombinant human brain natriuretic peptide in treating acute heart failure induced by acute myocardial infraction or dilated cardiomyomyopathy

目的探讨重组人脑钠肽(Lrh-BNP)对扩张型心肌病(DCM)及急性心肌梗死(AMI)所致急性心力衰竭(AHF)的治疗效果。方法 DCM或AMI导致的AHF患者133例分为四组:A组,32例,DCM常规治疗;B组,33例,DCM常规治疗+Lrh-BNP治疗;C组,35例,AMI常规治疗;D组,33例,AMI常规治疗+Lrh-BNP治疗。比较治疗后四组患者6-min步行距离、临床症状及心功能改善等情况。结果与A、C组比较,B、D组患者呼吸困难改善明显,6-min步行距离增加,治疗有效例数增加(P<0.05)。D组患者上述指标改善更为明显;D组脑钠肽(BNP)较B、C组明显降低[(367.5±134.6)pg/L vs.(602.5±213.1)pg/L、(489.3±145.5)pg/L](P<0.05)。结论 Lrh-BNP能改善AMI及DCM导致的AHF临床症状及心功能,对AMI后AHF的治疗作用更为明显。

Objective To investigate the efficacy of lyophilized recombinant human brain natriuretic peptide（Lrh-BNP） in treating acute heart failure（AHF） induced by acute myocardial infraction（AMI） or dilated cardiomyomyopathy（DCM）. Methods A total of 133 patients with AHF induced by AMI or DCM was divided into four groups of A（32 cases,conventional treatment for DCM）,B（33 cases,conventional treatment plus Lrh-BNP for DCM）,C（35 cases,conventional treatment for AMI） and D（33 cases,conventional treatment plus Lrh-BNP for AMI）.The cilinal symptoms,6-minute walking distance and heart function were compared among four groups. ResultsCompared to groups of A and C,dyspnea was slighter,6-minute walking distance was longer and effective cases of treatment were more in groups of B and D（P0.05）.The above indexes were improved more obvious in group D.The brain natriuretic peptide in group D was lower than that in groups of B and C [（367.5±134.6） pg/L vs.（602.5±213.1） pg/L and（489.3±145.5） pg/L]（P0.05）. Conclusion Lrh-BNP can improve heart function after AHF induced by AMI or DCM,especially in AHF induced by AMI.