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线粒体膜通透性转换孔结构与功能研究进展 被引量：19

Research progress of structure and function of mitochondrial permeability transition pore
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摘要 线粒体膜通透性变化在细胞凋亡或坏死中具有重要作用,线粒体膜通透性转换孔可影响线粒体膜通透性变化。目前对线粒体膜通透性转换孔的分子结构和功能尚不明确。文章对腺嘌呤核苷酸转位酶(ANT)、电压依赖性阴离子通道(VDAC)、亲环蛋白D(Cyp D)、磷酸盐载体(PiC)、Bcl-2蛋白家族等可能参与线粒体膜通透性转换孔结构组成或功能调节的分子研究进展进行综述。 The change of mitochondrial permeability plays an important role in the apoptosis and necrosis of cells,and mitochondria permeability transition pore may influence the change of mitochondrial permeability.However,the molecular structure and function of mitochondria permeability transition pore are not clearly revealed.The research progress of molecules involved in structure composition and function regulation of mitochondria permeability transition pore,including adenine nucleotide translocase（ANT）,voltage-dependent anion-selective channel（VDAC）,cyclophilin D（Cyp D）,phosphatic carrier（PiC） and Bcl-2 proteins is reviewed in this paper.
作者 冯阳 刘建军 黄钢
机构地区 上海交通大学医学院附属仁济医院核医学科
出处 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2012年第3期356-360,共5页 Journal of Shanghai Jiao tong University:Medical Science
基金 国家自然科学基金(30830038)~~
关键词 线粒体膜通透性转换孔 凋亡 坏死 mitochondrial permeability transition pore apoptosis necrosis
分类号 R341 [医药卫生—基础医学]
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参考文献32

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二级参考文献25

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共引文献7

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上海交通大学学报（医学版）
2012年 第3期

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