新生儿黄疸与胆红素脑病的临床分析

Clinical analysis of neonatal jaundice and bilirubin encephalopathy

目的探讨新生儿病理性黄疸与胆红素脑病时血清、脑脊液胆红素含量与病情评估。方法选取2006～2010年新生儿黄疸368例,检测血清及脑脊液中胆红素含量,比较两组患儿不同体液中胆红素浓度。结果胆红素脑病组血清及脑脊液中胆红素含量较病理性黄疸组明显升高(P<0.05),其含量高低同病情呈正相关(P<0.01),血清与脑脊液胆红素比值与病情无相关性(P>0.05)。结论血清及脑脊液胆红素可以作为胆红素脑病较敏感的诊断指标和病情评估指标。

Objective To analyze the serum and eerebrospinal fluid bilirubin containment of neonatal jaundice and biliru- bin encephalopathy and disease assessment. Methods Selected 368 cases of neonatal jaundice and bilirubin encephalopa- thy of newborns hospitalized between 2006 and 2010, to examine serum and cerebrospinal fluid containment, to compare cerebrospinal fluid levels between the two groups of children with different levels of body fluids. Results Serum and cere- brospinal fluid bilirubin containment for bilirubin encephalopathy group was obviously higher than that for pathologic jaun- dice group （P 〈 0.05）. There was a positive correlation between the containment level and disease condition（P 〈 0.01）, but there was no correlation between serum and cerebrospinal fluid bilirubin ratio and disease condition （P 〉 0.05）. Conclu- sion Serum and cerebrospinal fluid bilirubin can be used as more sensitive indices in the diagnosis and disease condition assessment of bilirubin encephalopathy.