盐酸卡替洛尔眼液预防超高度近视LASIK术后屈光回退的临床观察

Clinical study on preventive effects of carteolol hydrochloride on refractive regression for extreme high myopia after LASIK

目的:探讨盐酸卡替洛尔滴眼液在预防超高度近视准分子激光原位角膜磨镶术(LASIK)术后早期屈光回退中的作用。方法:超高度近视患者行LASIK治疗者68例136眼,随机分成试验组和对照组,所有患者术后第1d开始用1g/L氟米龙、1g/L玻璃酸钠和1g/L普拉洛芬滴眼液3次/d,1wk后试验组停用1g/L氟米龙滴眼液并且加用20g/L盐酸卡替洛尔滴眼液,术后1mo试验组和对照组患者均停用1g/L玻璃酸钠以外的其他滴眼液,术后随访6mo观察两术式的治疗效果。结果:术后3,6mo试验组患者裸眼视力≥1.0者、屈光度和对照组比较差异有显著性(P<0.05);术后1wk;1,3,6mo试验组眼压按时间点经重复测量方差分析比较两组差异有显著性(P<0.02);术后1mo试验组和对照组患者前房深度比较差异有显著性(P<0.05);术后3,6mo试验组患者角膜屈光力、角膜后表面Diff值和对照组比较差异有显著性(P<0.05)。结论:对于超高度近视患者,LASIK术后早期应用盐酸卡替洛尔滴眼液能预防屈光回退,使患者获得更持久的效果,但远期效果需进一步观察。

AIM：To make an analysis of preventive effects of carteolol hydrochloride on refractive regression for extreme high myopia after LASIK.METHODS：LASIK was performed in 68 cases of 136 eyes with extreme high myopic.All the cases were randomly divided into treatment group and control group.Carteolol hydrochloride was administered topically twice per day to the treatment group from the second week to the end of first month postoperatively.Uncorrected visual acuity（UCVA）,refration,slit-lamp examination,intraocular pressure（IOP）,topography examination and anterior chamber depth（ACD） were examined in these patients and the period of follow-up was 6 months.RESULTS：Three months and 6 months after surgery,there was significant difference of UCVA ≥1.0 and refraction between treatment group and control group（P0.05）.1 week,1 month,3 months and 6 months postoperatively the IOP in treatment group and control group were significantly different in different periods（P0.02）.There was significant difference of ACD between treatment group and control group 1 month after surgery（P0.05）.There were significant differences of corneal refractive power and posterior corneal Diff value between two groups 3 months and 6 months postoperatively（P0.05）.CONCLUSION：For extreme high myopia patients using carteolol hydrochloride after LASIK can stabilize the refraction and reduce refractive regression.