应用1/3剂量光动力学疗法治疗急性CSC

Efficacy of photodynamic therapy with 1/3 dose verteporfin for treating acute central serous chorioretinopathy

目的:观察1/3剂量光动力学疗法(photodynamic therapy,PDT)治疗急性中心性浆液性脉络膜视网膜病变(centralserous chorioretinopathy,CSC)的短期疗效。方法:选取急性CSC患者26例26眼,行单次1/3量维替泊芬(2mg/m2)进行PDT治疗,术前和术后1,4,12wk进行最佳矫正视力和OCT的检测,且于术前、术后4wk和12wk进行眼底荧光素血管造影(FFA),吲哚青绿血管造影(ICG)检查,观察治疗的有效性和安全性。结果:术后1wk,26眼中有20眼(77%)视网膜下积液吸收,其余6眼(23%)视网膜下液部分吸收;术后4wk,26眼视网膜下积液全部吸收,22眼荧光渗漏完全消失,脉络膜血管高渗透性消失;术后12wk,26眼均病情平稳,无复发。治疗后1wk,最佳矫正视力从术前平均0.41升高至0.80。随访期间26眼均未见任何不良反应。结论:1/3剂量PDT治疗急性CSC短期内安全有效。

AIM：To evaluate the efficacy of photodynamic therapy（PDT） after 1/3 dose verteporfin injection to treat acute central serous chorioretinopathy（CSC）.METHODS：Twenty-six eyes of 26 cases diagnosed with acute CSC by fundus fluorescein angiography（FFA） and optical coherence tomography（OCT） examination received one single session of PDT using 1/3 dose（2mg/m2） verteporfin.Best-corrected visual acuity（BCVA） was measured before,1 week,4 weeks,and 12 weeks after PDT with 1/3 dose.OCT,FFA and indocyanine green（ICG） examination were performed before,4 weeks,and 12 weeks after PDT with 1/3 dose.RESULTS：Twenty of 26 eyes（77%） had complete resolution of subretinal fluid（SRF） 1 week after 1/3 dose PDT treatment.After 4 weeks,SRF in 26 eyes was completely absorbed,fluorescein leakage of 22 eyes reduced in FFA and the tortuous choroidal vessels appeared normal in ICG;Twelve weeks after PDT,there was no recurrence of CSC in 26 eyes.The mean BCVA was improved from 0.41 to 0.80 1 week after PDT treatment.CONCLUSION：PDT with 1/3 dose verteporfin injection is effective and safe in treating acute CSC.