去势雌性山羊骨质疏松模型的特点

Characteristics of osteoporosis models of ovariectomized goats

背景:加强骨质疏松模型的研究,对骨质疏松性骨折的防治非常必要。目的:综述现有的山羊骨质疏松模型的特点,为骨质疏松和骨质疏松性骨折的防治提供帮助。方法:应用计算机检索中国知网和PubMed数据库中2005-06/2011-02关于去势雌性山羊骨质疏松模型的文章,在标题和摘要中以"骨质疏松症、动物模型、山羊、卵巢切除"或"osteoporosis,animal model,goats,ovariectomy"为检索词进行检索。选择文章内容与建立骨质疏松模型的方法、评价标准,骨质变化等有关的研究,排除重复研究及建立雄性动物骨质疏松模型的研究。结果与结论:初检得到48篇文献,根据纳入标准选择21篇文章进行综述。山羊来源方便,容易处置,具有自动排卵和与成年妇女相似的排卵周期,是理想的实验动物材料;能获取大量血、尿和骨骼标本,是理想的制备骨质疏松模型的实验动物。去势法是建立骨质疏松模型常用的方法,山羊骨质疏松模型的建立将为骨质疏松和骨质疏松性骨折防治药物的开发、改进内置物设计等提供研究的基础。

BACKGROUND：Strengthen the research of the osteoporosis（OP） model is necessary for the prevention of osteoporotic fractures.OBJECTIVE：To summarize the characteristics of OP goat model and provide help for prevention of OP and osteoporotic fractures.METHODS：A computer-based search on CNKI database and PubMed database 2005-06/2011-02 was performed for the articles about OP model in ovariectomized goats with the keywords of ＂osteoporosis,animal model,goats,ovariectomy＂ in English and in Chinese.The articles related with the method to establish the OP model,evaluation criteria,changes in bone,were included.The duplicated research and the articles about the establishment of the male animal models of OP were excluded.RESULTS AND CONCLUSION：Atotal of 48 articles were obtained,and finally,21 articles were included to summaize according to the inclusion criteria.Convenient source of goats,easy to disposal,and had the automatic ovulation cycle which were similar to adult women,so it was an ideal experimental animal material.A large amount of blood,urine and bone specimens could be ontained from goats,so the goats were the ideal experimental animal to establish the OP model.Castration method（OVX） is a commonly method to establish OP model,the establishment of goats OP model provided a research basement for the development of prevention drug for OP and osteoporotic fractures and the design of implant.