泡利芬对红细胞膜稳定性及红细胞寿命的影响

Effects of Paolifen on the stability of erythrocyte membrane and lifespan of RBC

目的 研究泡利芬对红细胞膜稳定性及红细胞寿命的影响。方法 采用整体和离体水平相结合的红细胞渗透性脆性实验方法。结果 不同受试组小鼠红细胞在低渗氯化钠溶液中的溶血百分率存在明显差异 (P<0 0 5) ; 在四种不同受试剂的 NH4Cl溶液中 ,兔红细胞数明显不同 ,差异具有显著性意义 (P<0 0 5) ,且随着泡利芬浓度的增高 ,离体兔红细胞被溶解的数量明显减少 ,红细胞数明显增加 ,表现出泡利芬对红细胞的保护性呈明显的浓度依赖性 ,同时 ,离体兔红细胞的溶血起、止时间也明显延长 (P<0 0 1 )。结论 泡利芬具有延长红细胞寿命 ,增强红细胞膜稳定性 ,延缓衰老的作用。

To study the effects of Paolifen on the stability of erythrocyte membrane and lifespan of RBC.Methods Erythrocyte osmotic fragility test(EOF) were conducted in vivo and vitro.Results Compared with control groups, the high, mid dose group had difference on dissolved blood's percentage in low osmotic NaCl solution (P<0 05) ; The counts of the rabbit's red blood cell were significant in difference NH 4Cl solutions.Conclusions Paolifen can slightly strengthen erythrocyte membrane stability and prolong the lifespan of RBC.