核素显像法门体分流率测定的动物模型实验及临床应用评价

Quantitate Portosystemic shunt estimated by Rectal Proral Scintigraphy in Animal Model and clinical evaluation of the patients

目的 应用 99m Tc0 4 直肠门脉显像定量门体分流率 ,与生理测压法结果进行比较 ,探讨本法的可靠性和临床价值。方法 2 0只狗及 2 2例肝硬化病人及 8例正常对照 ,直肠给入 1 0 m Ci 99m Tc0 4 后动态采集 ,计算门体分流率 ,与生理测压法结果进行相关分析。结果 核素显像法测得正常动物门体分流率与生理测压法所得结果无显著性差异 (P>0 0 5) ,呈高度正相关 (r=0 62 9)。核素显像法测得正常对照者的门体分流率为 4 0 0 %± 1 61 % ,与生理测压法相比无显著性差异 (P>0 0 5) ,呈高度正相关 (r=0 675)。核素显像法测得门脉高压症患者行分流术前后的门体分流率差异显著 (P<0 0 0 1 ) ,在门脉高压症患者与正常对照者存在显著性差异 (P<0 0 0 1 )。结论 核素显像法门体分流率测定 ,结果可靠 ,方法简便易行 ,可重复测定 ,具有较高的临床价值。

Portosystemic shunt were quantitated with per rectal portal scintigraphy and compared with results of presure measuring method in order to discuss the clinical value of this method.Methods 20 dogs and 22 patients with hepatocirrhosis and 8 normal volunteers were studied. Data were acquisited after the subjects were detected by 10 mCi 99m TcO - 4 and ROIs were drawed at heart and liver region, with the portosystemic shunt rates calculated.Results The portosystemic shunt of dogs measured with the two methods had no significant difference (P>0 05) , but with hign positive correlation (r=0 629) . The portosystemic shunt were 4.00±1.61 and 4.31±1.63 respectively, with no significant difference (P>0 05) , but with significant relativity (r=0 675) . The portosystemic shunt of patients with hepatocirrhosis measured by scintigraphy were 55.86±14.70 and 31.00±11.17 respectively before and after portocaval shunt operation.Conclusions Per rectal portal scintigraphy is precise to quantitate portosystemic shunt and valuble for clinical diagnosis and treatment of hepacirrhosis.