环孢素A联合化疗诱导治疗复发及难治性急性白血病8例临床分析

Induction treatment for relapsed and refractory acute leukemia with cyclosporin A combined with chemotherapy

目的评价环孢素A(CsA)与化疗方案联合应用治疗复发及难治性急性白血病的效果。方法对8例复发及难治性急性白血病进行诱导化疗。化疗方案由CsA、阿克拉霉素、或异环磷酰胺等组成。结果5例患者获完全缓解，另3例只进行了1个疗程化疗，可评价的2例均获部分缓解。所报告方案的毒性反应主要为骨髓抑制。结论化疗伍用CsA可能是治疗复发及难治急性白血病的有效方案。

objective To evaluate the effect of cyclosporin A (CsA) combined with chemotherapy in the treatment of relapsedand refractory acute leukemia. Methods 8 cases of relapsed and refractory acute leukemia were treated with the reportedregimens which contained CsA, aclarubicin or ifosfamide. Results Of the 8 patients, 5 achieved complete remission and 2 receiving only one course of the induction therapy achieved partial remission. The toxicity of the reported protocols was marrow suppression. Conclusion Chemotherapy agents combined with CsA would be eff ective for patients with relapsed and refractory acute leukemia.