酚妥拉明和多巴胺输液泵给药治疗婴幼儿重症肺炎并发心力衰竭

The Clinical Observation of Phentolamine and Dopamine by Continued Micro-pump Infusion for Infants with Severe Pneumonia Complicated by Heart Failure

目的:探讨酚妥拉明和多巴胺输液泵给药治疗婴幼儿重症肺炎并发心力衰竭的临床疗效。方法:将252例重症肺炎并发心力衰竭的住院患儿随机分为常规强心、利尿治疗的对照组和采用酚妥拉明和多巴胺输液泵给药治疗的治疗组,比较两组的临床疗效。结果:治疗组显效比例明显高于对照组,差异有显著的统计学意义(P<0.01);对照组有效比例明显高于治疗组,差异有显著的统计学意义(P<0.01);对照组无效比例明显高于治疗组,差异有统计学意义(P<0.05);治疗组在心衰纠正时间、治疗到症状缓解时间、治疗到细湿性啰音消失时间、住院天数等观察指标方面均明显短于对照组,差异有显著的统计学意义(P<0.01);治疗组在西地兰应用次数方面明显少于对照组,差异有统计学意义(P<0.05)。结论:酚妥拉明和多巴胺输液泵给药治疗婴幼儿重症肺炎并发心力衰竭疗效确切,心衰控制满意,值得临床推广应用。

Objective：To investigate the effect of phentolamine and dopamine by continued micro-pump infusion for infants with severe pneumonia complicated by heart failure. Methods： 252 cases of infants with severe pneumonia complicated by heart failure were randomly divided into 2 groups. The patients of control group underwent conventional cardiac and diuretic treatment. Patients in experimental group underwent continued micro-pump infusion with phentolamine and dopamine based on conventional treatment. The clinical efficacy of the two groups after treatment was compared. Results： The proportion of markedly effective rate in treatment group was significantly higher than that in the control group, the difference was statistically significant（P0.01）. The proportion of effective rate in the control group was significantly higher than that in the treatment group, the difference was statistically significant（P0.01）. The proportion of invalid rate in the control group was significantly higher than that in the treatment group, the difference was statistically significant（P0.05）. The time to correct heart failure, treatment to remission time, the treatment to the fine moist rales disappeared time, length of stay, and other observed indicators of the treatment group were significantly shorter than that in the control group, the difference was significant（P0.01）. The cedilanid application number in treatment group was significantly less than that in the control group, the difference was statistically significant（P0.05）. Conclusion： The treatment of phentolamine and dopamine by continued micro-pump infusion for infants with severe pneumonia complicated by heart failure is effective, and is satisfactory for the control of heart failure.