子痫前期患者脉压与蛋白尿相关性分析

Correlation Analysis of Pulse Pressure and Albuminuria in Patients with Pre-eclampsia

目的:探讨子痫前期患者脉压与蛋白尿的相关性。方法:按脉压高低将子痫前期患者分为脉压≤40mmHg、41～80mmHg、>80mmHg三组,比较各组蛋白尿的发生率。结果:三组间的收缩压、舒张压、蛋白尿发生率,24h尿蛋白浓度差异有统计学意义(P<0.05);SBP、DBP、平均动脉压和脉压与24h尿蛋白量的β值分别为0.425、0.331、0.357和0.486(P<0.05)。结论:脉压对尿蛋白的发生率有明显影响,临床上在治疗子痫前期患者时,不但要降低收缩压和舒张压,还要降低脉压,只有这样才能使肾脏的损伤程度减轻。

Objective：To explore the correlation of pulse pressure and albuminuria in patients with pre-eclampsia. Methods： All the subjects were divided into three groups： Ⅰ group（≤40 mm Hg）; Ⅱ group（41～80 mm Hg）; Ⅲ group（80 mm Hg）. The incidence rates of albuminuria of the three groups were compared. Results： There were no significant difference in gender and age. Significant differences in systolic blood pressure, diastolic blood pressure, incidence rates of albuminuria, and 24 hours albuminuria levels were found in the three groups. βvalues of 24 hours albuminuria levels between SBP, DBP, mean arterial pressure, and pulse pressure were 0.425, 0.331, 0.357, and 0.486（all P0.05）. Conclusion： Pulse pressure has significant effect on the incidence rates of albuminuria. In clinical decisions, we should not only reduce SBP and DBP, but also pulse pressure. Only in this way can we less the extent of renal damage.