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冠心病冠状动脉狭窄程度与ABO血型关系的初步研究 被引量：2

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摘要 目的:初步研究冠心病冠脉狭窄程度与ABO血型系统的关系。方法:对736例汉族冠脉造影患者的血型进行记录归类,并将ABO血型的分布情况与其冠脉造影结果进行对比分析。结果:对照组、单支病变组、双支病变组和多支病变组四组间ABO血型分布比较差异有统计学意义(P=0.03),并观察到冠脉病变累及血管数越多,非O型血的比例越高,B型血的检出比例也越高。各血型组的Gensini积分比较差异有统计学意义(P=0.037);A型组(28.75±10.23)分、B型(60.30±19.15)分、AB型(26.02±9.57)分,各组的Gensini积分均高于O型组(14.51±5.24)分,另外研究显示B型组的Gensini积分最高。结论:冠状动脉狭窄程度与ABO血型系统之间可能存在潜在关系,非O型血与冠脉狭窄相关,其中B型血与冠脉狭窄程度密切相关,值得进一步研究。
作者 吕云波
机构地区 宜昌市第一人民医院
出处 《中外医学研究》 2012年第8期31-32,共2页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 ABO血型 冠心病 GENSINI积分
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献9

  • 1Tirado I,Mateo J,Sofia J M,et a1.The ABO blood group genotype and factorⅧlevels as independent risk factors for venous thromboembolism[J].Thromb Haemost,2005,93(3):468-474.
  • 2Schleef M,Strobel E,Dick A,et a1.Relationship between ABO and Secretor genotype with plasma levels of factorⅧand yon Willebrand factor in thrombosis patients and control individuals[J].Br J Haematol,2005,128(1):l00-107.
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二级参考文献30

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共引文献6

同被引文献31

  • 1上海医科大学《实用内科学》编委.实用内科学[M].北京:人民卫生出版社,1993:1095-1104.
  • 2Carpeggiani C,Coceani M,Landi P, et al. ABO blood groualle- les: A risk factor for coronary artery disease. An angiographic study[J. Atherosclerosis,2010,211(2) =46D466.
  • 3Tirado I, Mateo J, Sofia JM, et al. The ABO blood group genotype an factor levels as independent risk factors for venous thrombo- embolismJ. Thromb Haemost, 2005,93 (3) .- 468-474.
  • 4Schleef M,Strobel E,Dick A, et al. Relationship between ABO an Secretor genotype with plasma levels of factor N and yon Willebrand factoin thrombosis patients and control individuals [J. Br J Haematol,2005,128(1) : 100-107.
  • 5李大鹏,靳丽,刘文清,等.鲁中南地区冠心病患者的ABO血型相关性研究[J].2008,36(3):425426.
  • 6yon Beckerath N, Koch W, Mehilli J. et al. ABO locus O1 al lele an risk of myocardial infarction[-J. Blood Coagul Fibri nolysis,2004,15 (1) :61-67.
  • 7Sail L,Ozer O,Davutoglu V,et al. ABO blood group distribu tion and majorcardiovascular risk factors in patients with a cute myocardia infarction E J 1. Blood Coagul Fibrinolysis 2008,19(3) 231-234.
  • 8Reilly MP, Li M, He J, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies [J]. Lancet, 2011, 377(9763): 383-392.
  • 9Williams FMK, Carter AM, Hysi PG, et al. Ischemie stroke is asso- ciated with the ABO locus: The EuroCLOT study [J]. Ann Neurol, 2013, 73(1): 16-31.
  • 10Karakas M, Baumert J, Kleber ME, et al. A variant in the abo gene explains the variation in soluble E-Selectin levels-Results from dense genotyping in two independent populations [J]. PLoS One, 2012, 7(12): e51441.

引证文献2

二级引证文献9

中外医学研究
2012年 第8期

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