坎地沙坦和吲达帕胺联合治疗老年糖尿病合并高血压的疗效观察

Clinincal Effect of Candesartan and Indapamide in Treatment of Old Patients with Diabetic Mellitus and Hypertension

目的:观察坎地沙坦与吲达帕胺联合治疗老年糖尿病合并高血压的临床疗效及预后。方法:将150例确诊糖尿病合并高血压的老年患者随机分为治疗组和对照组。治疗组(78例)用坎地沙坦加吲达帕胺治疗,对照组(72例)用硝苯地平控释片加吲达帕胺治疗。12周后比较治疗前后的降压幅度、降压效果、降糖疗效及心率、血清钾、钠及总胆固醇变化,12个月后随访两组心脑血管事件发生情况。结果:治疗组降糖疗效优于对照组,心脑血管事件发生率低于对照组(P<0.05);但两组均有显著的降压疗效(P<0.01),组间降压效果差异无统计学意义(P>0.05);治疗前后两组心率、血清钾、钠及总胆固醇均无明显变化。结论:坎地沙坦与吲达帕胺联用可作为治疗老年糖尿病合并高血压的一种较好的治疗方案。

Objective ：To investigate the clinical efficacy and prognosis for diabetic hypertension among old patients by combined treatment of candesartan and indapamide.Methods： A treatment group and a contrast group were formed randomly by 150 cases of old patients which were diagnosed diabetic hypertension. The treatment group （78 eases） were remedied by eandesartan and indapamide, meanwhile the contrast group （72 cases） were remedied by nifedipine controlled release tablets and indapamide. After treatment for 12 weeks, comparison was made for range and effect of drop of blood pressure, therapeutic efficacy for drop of blood glucose, heart rate, serum potassium, sodium as well as total cholesterol. And 12 months later, revisit was made to the occurrence of cardiovascular and cerebrovascular disease. Results ： Therapeutic efficacy for drop of blood glucose excelled in treatment group, and rate of occurrence for cardiovascular and cerebrovascular disease was lower in treatment group（P〈0.05）; But both groups have significant antihypertensive effects （P 〈 0.01）, Differences between groups hypotensive effect was not statistically significant （P〉 0.05）; variation of heart rate, serum potassium, sodium and total cholesterol in both two groups was not noticeable before and after therapy. Conclusion ： The combined treatment of candesartan and indapamide is comparably better for agedness diabetic hyoertension.