血必净注射液对严重腹腔感染病人肠道功能及炎症反应的影响

Xue Bi Jing injection impact on patients with severe abdominal infection intestinal function and inflammation

目的:探讨血必净注射液对严重腹腔感染病人肠道功能及炎症反应的影响。方法:将同期严重程度相当的32例严重腹腔感染病人随机(随机数字法)分为血必净治疗组(n=16)和对照组(n=16)。对照组按腹腔感染常规治疗;治疗组在常规治疗基础上给予血必净注射液,每次100ml,静脉滴注,2次/d,连续使用7d。检测两组患者治疗前与治疗后3d和7d血浆二胺氧化酶(DAO)、内毒素(LPS)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平变化,同时观察病情严重程度(APACHEII评分)和氧合指数(OI)的变化。采用SPSS12.0统计软件进行统计分析。结果:两组腹腔感染病人治疗后,血浆DAO,LPS,TNF-α,IL-6较治疗前下降(P<0.05);APACHEII评分和OI改善。血必净注射液可保护腹腔感染病人肠道功能,减少内毒素入血,对改善严重腹腔感染病人的炎症反应有积极作用,从而改善预后。

Objective： To investigate the Xue Bi Jing injection to patients with intestinal function and inflammatory response in severe abdominal infection.Methods： 32 cases of severe abdominal infected patients were randomly divided into Xue Bi Jing treatment group and control group,16 each.The control group according to intraperitoneal infection with conventional treatment;the treatment group on the basis of conventional therapy Xue Bi Jing injection,once 100ml,intravenous infusion,2 times / d,continuous use of the 7days.Two groups were detected in patients with plasma diamine oxidase（DAO）,endotoxin（LPS）,tumor necrosis factor-alpha（TNF-a）,interleukin prime-6（IL-6） levels,while observing the severity of the disease（APACHEIIchanges in the score） and oxygenation index（OI） before treatment and after treatment,3 and 7 days.The SPSS12.0 Statistics software for statistical analysis.Results： Two sets of abdominal infection patients after treatment,the plasma the DAO,LPS and TNF-alpha,IL-6 compared with before treatment（P〈0.05）;APACHEII score and OI improve.The Xue Bi Jing injection to protect the abdominal infection in patients with bowel function,reduce endotoxin into the blood,have a positive effect to improve the inflammatory response of patients with severe abdominal infection.