上海地区11年急性白血病初治缓解率观察

Current status of complete remission rate of acute leukemia in Shanghai

目的 总结初发急性白血病的疗效及影响因素。方法 对上海地区 2 5 18例初发急性白血病进行回顾性临床总结和分析。结果和结论 急性白血病总完全缓解 (CR)率为 6 0 .4% ,急性髓系白血病 (AML)的CR率为 5 1% ,急性淋巴细胞白血病 (ALL)为 76 .7%。儿童ALL的CR率最高 ,达87 1% ,老年人AML的CR率最低 ,仅为 2 6 %。 1984～ 1994年除M3 的CR率有明显提高外 ,AML和ALL的CR率均无明显提高。诱导缓解方案对CR率有一定影响 ,维甲酸对M3 的疗效再次得到肯定。对ALL患者采用VDLP和VDP方案治疗的疗效优于VP方案。DA和HA方案治疗AML的CR率差异无显著性。

Objective To investigate the treatment outcome in newly diagnosed acute leukemia patients.Methods Two thousand five hundred and eighteen patients with acute leukemia registered in Shanghai were retrospectively analyzed.Results and Conclusions The overall complete remission(CR) rate of acute leukemia was 60 4%: 51% for acute myeloid leukemia(AML) and 76.7% for acute lymphoid leukemia(ALL). CR rate of childhood ALL was 87.1%, while of elderly AML only 26%. Between 1984 and 1994, CR rates of AML and of ALL were not increased except for that of AML M 3. Induction regimen was associated with CR rate. All transretinoic acid was effective for AML M 3. The VDLP and VDP regimens were more effective than that of VP regimen for ALL patients. There was no significant difference in CR rate between DA and HA regimens for treatment of ALL patients.