血清C反应蛋白检测在小儿支原体肺炎感染中的临床价值

Value of C-reactive Protein Detection in Children with Mycoplasma Pneumonia Infection

目的:探讨血清C反应蛋白检测在小儿支原体肺炎感染中的临床价值。方法:采用免疫比浊法测定98例支原体肺炎(支原体肺炎组)和67例细菌性肺炎患儿(细菌性肺炎组)血清CRP,与72例健康儿童(健康对照组)作对比。结果:入院时支原体肺炎组和细菌性肺炎组CRP均值和阳性率均显著高于对照组(P<0.05),且细菌性肺炎组显著高于支原体肺炎组(P<0.05);治疗1周后,两组CRP和阳性率指标较入院时均明显下降,支原体肺炎组与健康对照组比较无差别(P>0.05),但细菌性肺炎组仍高于支原体肺炎组和健康对照组(P<0.05);所有病例在入院时CRP和MP-IgM检测为阳性者,4岁以下儿童为59.13%(68/115),4岁以上为40.87%(47/115),其中年龄最小的仅生后2个月。结论:对于支原体肺炎患儿CRP稍高,但没有细菌性肺炎增高明显,CRP可作为鉴别支原体肺炎或细菌性肺炎的重要辅助指标。

Objective： To explore the diagnostic value of C-reactive protein（CRP） in infant with mycoplasma pneumonia.Method： The serum CRP levels were measured by nephelometric immunoassay and ELISA in 98 infants with mycoplasma pneumonia（mycoplasma pneumonia group） and 67 infants with bacterial pneumonia（bacterial pneumonia group） 72 healthy children（control group）.Result： Mean CRP levels of the pneumonia group and bacterial pneumonia group on admission were signifcantly increased（P0.05） and the order of the value of the two groups from high to low： bacterial pneumonia group mycoplasma pneumonia group（P0.05）;After a week＇s treatment,the CRP levels of the two groups were signifcantly decreased comparing with the admission day,the mycoplasma pneumonia group＇s CRP level was the same with normal value（P0.05）,however,the bacterial pneumonia group＇s CRP level was still higher than mycoplasma pneumonia group＇s and the control group＇s（P 0.05）;Among 115 childern whose CRP level were increased in admission,68 children（59.13%） were younger than 4 years old,47 children（40.87%） were 4 years old or older than 4,and the youngest of them was only 2 months.Conclusion： The CRP level for children with mycoplasma pneumonia is slightly higher than normal value,but lower than that of bacterial pneumonia.CRP can be used as an important auxiliary index of identification of mycoplasma pneumonia or bacterial pneumonia.