高同型半胱氨酸血症与脑血管疾病风险相关性研究

Association between serum homocysteine and cerebrovascular disease

目的通过分析临床病例,回顾性探讨血清同型半胱氨酸(Hcy)水平与脑血管疾病风险的相关性。方法采用循环酶法测定195例脑卒中患者和133例健康对照组的血清Hcy水平,两两比较采用t检验,多个样本之间的比较采用单因素方差分析。结果脑卒中患者组内有无糖尿病、高血压、高血脂、吸烟史和酗酒史的Hcy水平差异不具有统计学意义(P<0.05),一些脑卒中危险因素的有无与Hcy水平之间有一定的相关性。脑卒中组内男性血清Hcy与女性相比,差异具有统计学意义(P<0.05)。缺血性脑卒中与失血性脑卒中之间血清Hcy差异不具有统计学意义(P>0.05)。脑卒中不同类型之间Hcy水平差异不具有统计学意义(P>0.05),但动脉粥样硬化性血栓性脑梗死(ATCI)、脑腔梗、脑栓塞(CI)和脑出血的血清Hcy水平均高于短暂性脑缺血发作(TIA)和蛛网膜下腔出血(SAH)组。结论高Hcy血症是脑卒中的独立危险因素,并且与部分传统危险因素有一定的相关性。

Oblective To investigate the relationship between homocysteine （Hcy） and stroke in older patients. Methods Serum Hcy concentration was measured using cycling enzymatic method in 195 stoke patients and 133 healthy people. Two samples was compared by t test,the comparison between multiple samples using analysis of variance. Results The result showed that there were not statistically significantdifferences in serum Hcy level between patients with diabetes, hypertension, high cholesterol,smoking and alcohol history and without them（ P〉 0. 05） ,but presence or absence of certain risk factors had some relevance with Hcy levels for stroke. The difference is statistically significant between male stroke patients and female （P 〈 0.05）. The difference was not statistically significant between ischemic stroke and hemorrhagic stroke（P〉0.05）. Hcy levels in different types of stroke was not statistically significant difference （P 〉 0.05）, but Hey levels of ATCI, brain stem cavity, CI and cerebral hemorrhage were higher than TIA and SAH group. Conclusion High Hcy hyperlipidemia is an independent risk factor for stroke, and there are some correlations with the traditional risk factors.