吲哚与亚胺的Friedel-Crafts反应的研究进展

Research Progress in Friedel-Crafts Reaction of Indoles and Imines

由于吲哚类化合物具有许多生物特性等优点,在众多天然产物和相应的具有生物活性的化合物中起重要的骨架构筑作用,其合成方法的研究格外令人注目.近年来,关于吲哚与亚胺在催化剂作用下发生Friedel-Crafts反应来制备3-取代吲哚甲胺衍生物的报道剧增.对近年来吲哚与亚胺Friedel-Crafts反应的研究情况进行了综述.

Indole derivatives have a variety of merits,which have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds.Recently,there are a lot of reports on the synthesis of 3-indolylmethylamine derivatives via the Friedel-Crafts reaction of indoles and imines.The research progress in these catalytic Friedel-Crafts reactions of indoles and imines is reviewed.