二取代烯基硼酸的氯化反应研究

Chlorination Reaction of Disubstituted Alkenylboronic Acids

由二取代烯基硼酸[4-substituted-1,2-oxaborol-2(5H)-ol]与N-氯代丁二酰亚胺(NCS)在甲醇中常温反应0.5 h,可以中等到良好的收率构型保持地合成得到取代的(Z)-3-氯烯丙醇,产物经1H NMR,13C NMR,FT-IR,MS和HRMS鉴定.通过该方法合成取代的(Z)-3-氯烯丙醇操作简便,反应条件温和,收率较高且反应构型能够得到保持.

The chlorination reaction of 4-substituted-1,2-oxaborol-2（5H）-ols with N-chlorosuccinimide（NCS） afford（Z）-2-substituted-3-chloroallyl alcohol in moderate to good yields under the optimized condition.The structures of the products were identified by 1^H NMR,13^C NMR,FT-IR and MS techniques.This method is simple,mild,high yield and the configuration is maintained.