小剂量强力霉素联合甲硝唑凝胶治疗酒渣鼻疗效观察

The Therapeutic Effect of Small Doses Doxycycline Combine Metronidazole Gel for Rosacea

目的观察小剂量强力霉素联合甲硝唑凝胶治疗酒渣鼻的临床疗效和安全性。方法将入选的90例酒渣鼻患者随机分成3组,各30例,治疗组口服强力霉素20mg,同时外搽0.75%甲硝唑凝胶,均2次/d;对照1组仅口服强力霉素,对照2组仅外用0.75%甲硝唑凝胶,用法同治疗组,均4周为1个疗程,共治疗3个疗程。每个疗程结束后分别观察疗效。结果治疗组有效率(96.55%)明显优于对照1组(75.00%)和对照2组(76.67%),差异均有统计学意义(P均<0.05),而对照1组有效率和对照2组比较差异无统计学意义(P>0.05)。治疗组不良反应发生率为10.34%、对照2组为13.33%,该两组均表现为用药局部皮肤轻度干燥,对照1组未见不良反应。结论小剂量强力霉素联合甲硝唑凝胶外搽治疗酒渣鼻疗效肯定,安全性好。

Objective To observe the clinical efficacy and safety of small doses doxycycline combined with topical metronidazole gel in the treatment of rosacea. Methods Ninety cases of rosacea were divided randomly into three groups,the treatment group （n=30） were given doxycycline 20mg orally plus 0.75% metronidazole gel topically twice a day. The control group 1 （n=30）only orally took doxycycline 20rag two times per day ,and the control group 2 （n=30）only applied 0.75%o metronidazole gel twice a day： All groups had been given four-week courses. Results Total efficiency in the treatment group was 96.55%, which was better than that of control group 1 （75.00%）and the control group 2（76.67%0）（P 〈 0.05）;There was no satistical diffrence between the control group 1 and the control group 2（P 〉 0.05）. Mild local desiccation occured equally in both the treatment group and the control group 2, adverse reaction rate were 10.34% in the treatment group and 13.33% in the control group 2. Adverse reaction was not be founded in the control group 1. Conclusion The combination therapy of small doses of doxycycline and topical metronidazole gel is safe and effective in the treatment of rosacea.