胃肠道微乳头状癌的研究现状

Advances in Research on Gastrointestinal Invasive Micropapillary Carcinoma(GIMPC)

胃肠道微乳头状癌发生率低,其临床病理学特征与普通腺癌大多相似,但浸润更深,并且易于发生淋巴结转移。胃肠道微乳头状癌具有特征性的免疫表型即MUC1/EMA在细胞簇基质面表达,与普通腺癌在腺腔面表达的特点正好相反。目前对胃肠道IMPC分子病理学特点认识极为有限。胃肠道微乳头状癌由于生存率低,预后差,在临床工作中具有重要的鉴别诊断意义,尤其需要与乳头状腺癌、伴多量脉管瘤栓的普通腺癌、转移性微乳头状癌和肿瘤芽等鉴别。胃肠道微乳头状癌是一种在组织学形态、免疫表型和生物学行为上不同于胃肠道普通腺癌的特殊类型。

Gastrointestinal invasive micropapillary carcinoma （ GIMPC ） is a rare subtype of adenocarcinoma in the gastrointesti- nal tract. Compared with conventional adenocarcinomas, GIMPC is more progressive, and its outcome is rather unfavorable. Immuno- histostaining of Mucin 1/epithelial membrane antigen is evident on the stromal-facing surface of clusters of neoplastic cells. A broad dif- ferential diagnosis, including the papillary adenocarcinoma, the conventional adenocarcinoma with multiple lymphovascular invasion, metastic micropapillary carcinoma, and tumor buds, should be considered. GIMPC is distinct from conventional adenocarcinoma in terms of morphology, immunophenotype, and biological behavior. It is highly aggressive and exhibits poor prognosis.