子痫前期患者凝血指标的监测及其临床意义

The monitoring and significance in plasma coagulation of preeclampsia patients

目的探讨子痫前期患者血浆凝血指标的变化及意义。方法采用非妊娠妇女组40例(对照组)、正常晚期妊娠组40例、子痫前期组40例进行血浆凝血指标的监测分析。结果子痫前期组与对照组比较,凝血酶原时间(PT)缩短、纤维蛋白原(Fib)增高、D-二聚体升高,差异有统计学意义(P<0.05);子痫前期组与正常晚期妊娠组比较,PT缩短,Fib、D-二聚体升高,差异有统计学意义(P<0.05)。结论子痫前期患者存在凝血功能异常与纤溶抑制功能亢进,提示监测发现凝血指标明显异常者,有利于指导高危妊娠临床诊断、早期干预,预防产后出血、DIC等分娩期并发症的发生。

To discuss the significance and changes in plasma coagulation of preeclampsia patients. Methods The plasma coagulation of 40 non -pregnant women （the control group）, 40 normal late pregnancy and 40 preeclampsia was measured and analyzed. Results Preeclampsia group compared with control group, prothrombin time shortened, fibrinogen elevated and D - dimmer elevated （P 〈 0.05 ） ; preeclampsia group compare with normal late pregnancy, prothrombin time shortened, fibrinogen and D -dimmer elevated （P 〈 0.05）. Conclusion There are coagulopathy and fibrinolysis hyperthyroidism in the preeclampsia patients which prompts detected significant abnormalities in coagulation and that is benefit to guide the clinical diagnosis of high - risk pregnancy, early intervention, prevention of postpartum hemorrhage, DIC and other intrapartum complications.