含肿瘤坏死因子血清导致恶性疟原虫危象的研究

TUMOR NECROSIS SERUM INDUCE PLASMODIVM FALCIPARVM CRISIS FORM

本文就含肿瘤坏死因子的肿瘤坏死血清(TNS)对恶性疟原虫的影响进行了体外研究。TNS来自卡介苗和细菌内毒素刺激后的兔血清。结果表明:当TNS稀释度为1:3、1:6和1:12时,6h即对恶性疟原虫发生作用,12h后红细胞感染率下降,疟原虫裂殖体退化,裂殖子数目减少,24h后1:3稀释度的TNS仍使红细胞感染率下降,裂殖体呈现固缩状态。

This paper reports that tumor necrosis serum (TNS) containing tumor necrosis factor (TNF) could inhibite Plasmodium falciparum in vitro, TNS was obtained from rabbits given macrophage-activiting agent Mycobacterium tuberculosis (BCG)followed by intravenous administration of bacterial endotoxin (LPS). The results showed that TNS dilutions of 1:3, 1:6 and 1:12 cauld induce disappearance of Plasmodium falciparum (P<0.05) after being cultured 6 hours. TNS decreased red blood cell infective rate of the parasites as compared with the control (P<0.05) after 12 hours' cultivation. TNS of 1:3 dilution had further effect at 24 hours (P<0.05). Morphological observations showed that the growth of schizonts was retarded and abnormal merozoites were found.