自锁托槽矫治中龈沟液天冬氨酸转氨酶水平的变化及其生物学意义

Changes of the aspartate aminotransferase level in gingival crevicular fluid during orthodontic therapy with self-ligating appliance and their biological significance

目的分析应用自锁托槽矫治器在错颌畸形矫治早期龈沟液天冬氨酸氨基转移酶(AST)水平的变化,探讨自锁托槽矫治对早期牙周组织改建的影响。方法选择20例青少年患者,年龄11～16岁,每例患者随机选取同颌同名牙列分别作为实验组和对照组,实验组牙列佩戴自锁托槽矫治器;同颌对侧牙列佩戴普通直丝弓托槽,设为对照组。利用全自动生化分析仪检测矫治前、矫治后1 h、24 h、48 h、72 h、168 h及2周龈沟液中AST含量水平的变化。结果佩戴自锁托槽矫治器牙列的龈沟液AST含量水平在加力24 h开始升高,但升高的幅度、速率明显小于佩戴普通直丝弓托槽矫治器的对照组牙列。结论牙齿正畸过程中受机械力的作用龈沟液AST水平发生动态变化。使用自锁托槽矫治器,龈沟液AST含量水平改变较小。相对普通直丝弓托槽,自锁托槽在牙齿矫治过程中,对牙周组织的损伤更小。

Objective This study aims to explore the changes of the aspartate aminotransferase （AST） level in gingival crev- icular fluid （GCF） during the early stage of orthodontic therapy with self-ligating appliance, and discuss the relationship between AST and periodontal tissue remodeling for this therapy. Methods We enrolled in this study 20 patients aged 11 to 16 years, and divided each dentition into an experimental and a control group, the former treated with self-ligating appliance and the latter with straight wire appliance for the contralateral dentition. We collected GCF samples before and at 1 h, 24h, 48h, 72h, 168h and 2wk after the treat- ment, and observed the changes of the AST level by automatic biochemical analysis. Results The AST level in the experimental group began to increase at 24 h, but at a significantly lower rate than that of the control group. Conclusion The AST level in GCF changes under the mechanical force during orthodontic therapy. Self-ligating appliance causes less change in the AST level than straight wire appliance, and therefore inflicts less damage to the periodontal tissue during orthodontic therapy.