骨性关节炎实验室诊断指标的意义及研究进展

Laboratory indicators of osteoarthritis:Significance and research progress

骨性关节炎(osteoarthritis,OA)是常见的关节退行性疾病。其主要病理改变是关节软骨的退行性变和继发性骨质增生。OA的诊断目前多依据影像学检查,但敏感性较差,出现影像学征象时往往已经出现骨质破坏以及增生,通常需要手术治疗才能缓解症状。多项研究表明某些实验室指标可在影像学征象出现前对OA进行早期诊断,积极干预和治疗,以提高患者生活质量。文中就目前对OA诊断较为明确的实验室诊断指标的检测方法、临床意义及其研究进展进行综述。

Osteoarthritis （OA） is a common joint degenerative disease with articular cartilage degeneration and secondary bone hyperplasia as its main pathological changes. At present, the diagnosis of OA is mostly based on radiography, but it is poor in sensibility, and in most cases reveals the changes only when apparent bone destruction and hyperplasia become obvious and surgery usually necessitated. Many studies show that some laboratory indicators can be used to diagnose OA earlier than visible changes reflec- ted on medical imaging, and thus contribute to early intervention and improvement of the patients＇ quality of life.