摘要
E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting （Peli） proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine （K） 63- and K48-1inked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors （TLRs） and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivofunctions of Pelil in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Pelil to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli I responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli.
E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting （Peli） proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine （K） 63- and K48-1inked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors （TLRs） and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivofunctions of Pelil in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Pelil to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli I responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli.
