胱抑素C联合尿微量白蛋白在高血压肾病诊断价值

Value of Combination of Cystatin C with Microalbumin in the Diagnosis of Hypertension Nephritis

目的分析血胱抑素C(Cys C)、尿微量白蛋白(mALB)和血肌酐(Cr)单独或联合应用在高血压肾病中的诊断价值。方法检测38名高血压患者和43名正常对照Cys C、mALB和Cr,首先比较对照组和高血压组3个指标有无显著性差异,然后通过典型判别方差分析检验3个指标对诊断高血压肾病的诊断价值。通过卡方检验比较3个指标阳性率,将Cys C分别与mALB和Cys C组合,比较检测阳性率。结果高血压患者血Cr和正常对照比较有显著性差异。Cys C在诊断高血压肾病中诊断价值高于mALB和Cr。Cys C和尿mALB组合诊断高血压肾病显著高于Cys C和Cr。结论随机尿mALB可以作为高血压肾病筛查指标,Cys C能够显著提高高血压肾病检测率。Cys C和尿mALB组合能够显著提高高血压肾病检测率。

Objective To explore the value of Cystatin C （ Cys C） , creatinine （Cr） and microalbumin （mALB） alone or combined in the diagnosis of hypertension nephritis （HN）. Methods The level of Cys C, mALB and Cr was compared between 38 hypertension patients and 43 healthy controls. The contribution of Cys C, mALB and Cr in the diagnosis of HN was compared by regularized discriminant analysis. The diagnostic positive rate of combined Cys C and mALB or Cr was compared by chi - square statistics. Results The concentration of Cr was significantly higher in hypertension patients than that in healthy control. The diagnostic value of Cys C was significantly higher than mALB and Cr. The diagnostic value of combine Cys C with mALB in HN could be significantly increased compared with that of Cys C and mALB alone. Conclusion Random urine mALB detection is suitable for screening of HN. The combination of Cys C with mALB could significantly increase the diagnostic positive rates of HN.