川崎病并发冠状动脉病变研究进展

Progress in Kawasaki disease with coronary artery lesions

川崎病是一种原因未明的急性全身血管炎性疾病，其主要并发症为冠状动脉病变，包括冠状动脉扩张、冠状动脉瘤形成等，且急性期过后冠状动脉损害持续存在。近年来研究表明，基因多态性、中性粒细胞、单核细胞、细胞因子等多种因素共同参与了冠状动脉病变的形成，长期抗凝药物的使用可降低冠状动脉损害。

Kawasaki.ki disease, which is an acute multisystem vasculitis of unknown cause, leads to pathognomonic feature of coronary artery lesion. Recent studies show that genetic polymorphism, neutrophils, monocytes, cytokines and other factors are involved in the development of coronary artery disease. Long-term use of anticoagulant drugs may reduce coronary artery damage.