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Kisspeptin在性发育中的作用

The role of Kisspeptin in sexual development
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摘要 性发育启动始于促性腺激素释放激素（gonadotrophichormone，GnRH）神经元脉冲发放GnRH的增加，导致卵泡刺激素和黄体生成素分泌增加，进而下丘脑一垂体一性腺（hypothalamicpituitarygonad，HPG）轴启动。I-IPG轴在不同生长发育阶段的神经内分泌表现不同，存在性别差异、季节差异等。多种激素可通过调节GnRH分泌，实现对HPG轴的调控作用。Kisspeptin是GnRH的强有力促泌剂，KISSl基因是性腺激素、代谢因素、光照及季节因素的作用靶点。该文对Kisspeptin在性发育中的作用作一综述。 Activation of gonadotrophic hormone neuronstion and downstream reproductive hormones （luteinizing hormone and follicle stimulating hormone） secretion is the key event representing the onset of puberty. Hypothalamic pituitary gonad axis varies among gender, season and the stage of development. A number of hormones are involved in the control of hypothalamic pituitary gonad axis. Kisspeptins are potent secreta- gogues for gonadotrophic hormone,and the KISS1 gene is a target for regulation by gonadal steroids, metabolic factors, photoperiod, and season. This review focuses on Kisspeptin in the regulation of sexual development.
作者 董红(综述) 李嫔(审校)
机构地区 上海市儿童医院上海交通大学医学院附属儿童医院内分泌科
出处 《国际儿科学杂志》 2012年第2期142-144,共3页 International Journal of Pediatrics
基金 上海市科委医学引导项目（09411963100）
关键词 KISSPEPTIN G蛋白耦联受体54 促性腺激素释放激素 下丘脑-垂体-性腺轴 Kisspeptin G-protein-coupled receptor 54 Gonadotrophic hormone Hypothalamic pituitarygonad axis
分类号 R779 [医药卫生—眼科]
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参考文献30

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二级参考文献25

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国际儿科学杂志
2012年 第2期

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