摘要
生命早期营养状况与成年期肥胖及代谢综合征的发生密切相关。脂代谢异常是影响成年期疾病发生的重要机制。肝脏是脂代谢的主要场所，进行脂肪酸的摄入、合成、酯化、氧化及输出。生命早期不良营养环境使肝脏及其组织结构的发育、细胞数目和代谢功能产生适应性的改变，持续影响后期肝脏脂代谢的各个途径，研究并阐明早期营养对肝脏脂代谢功能的程序化影响及其相关的分子调控机制，可为成年期疾病的早期防治提供理论依据及潜在的分子靶标。
The early life of nutrition is closely related to obesity and metabolic syndrome in adult. Lipid metabolic dysfunction is one of the important mechanisms in the development of adult diseases. Liver plays a key role in lipid metabolism. Hepatic lipid metabolism mainly includes fatty acid uptake, synthesis, esterification, oxidation and export. Exposed to a optimal nutrition environment in early life might lead to some adaptive effects in the liver and its organization structure, cell numbers and metabolic function. These adaptive responses might play a persistent effect in each way of hepatic lipid metabolism. Clarifying the programming effect of early nutrition on hepatic lipid metabolism and the relative molecular mechanism might provide related theoretical basis and practical molecular target for the prevention of adult diseases during childhood.
出处
《国际儿科学杂志》
2012年第2期147-150,共4页
International Journal of Pediatrics
关键词
早期营养
肝脏脂代谢
程序化
Early nutrition
Hepatic lipid metabolism
Programming
