定君生治疗外阴阴道假丝酵母菌病的临床疗效及复发率比较

The clinical effects of Live Preparation of Lactobacillus in treatment of vulvovaginal candidiasis and the recurrence rate

目的探讨定君生治疗外阴阴道假丝酵母菌的临床疗效及复发情况。方法将86例外阴阴道假丝酵母菌病患者随机分为对照组(n=43)和治疗组(n=43),对照组阴道塞入克霉唑栓,治疗组在对照组的基础上阴道塞入定君生胶囊,连续应用10 d。对两组临床疗效及复发率进行分析。结果用药第5天,治疗组总有效率显著高于对照组(83.72%vs 65.12%,P<0.05);用药第10天,两组总有效率比较差异无统计学意义(95.35%vs 90.70%,P>0.05);经治疗后,两组患者用药第5天和用药第10天其临床症状评分均显著下降,与治疗前比较差异有统计学意义(P<0.05);治疗组用药第5天临床症状评分显著低于对照组,两组比较差异有统计学意义(P<0.05);治疗组复发率显著低于对照组(9.30%vs 27.91%,P<0.05)。结论治疗外阴阴道假丝酵母菌病时,定君生联合克霉唑栓较单用克霉唑栓临床疗效果好,且能有效降低复发率。

Objective To explore the clinical effects of Live Preparation of Lactobacillus in the treatment of vulvovaginal candidiasis and the recurrence rate. Method 86 cases with vulvovaginal candidiasis were divided into control group （ n = 43 ） and treatment group （ n = 43 ）. The patients of control group were treated with Clorimazole Suppositories and those of treatment group with Live Preparation of Lactobacillus plus clorimazole suppositories for 10 days. The clinical effects and recurrence rates were analyzed. Result The total effective rate of treatment group was higher than control group （83.72% vs 65.12% , P 〈0.05） on the 5th day. There was no significant difference in total effective rates on the lOth day （95.35% vs 90.70% , P 〉 0.05 ）. After treatment, the clinical symptoms scores of two groups had fallen significantly on the 5th and lOth day （ P 〈 0. 05 ）. The clinical symptoms score was lower in treatment group than in control group on 5th day （ P 〈 0.05 ）. There was no significant difference in clinical symptoms scores on 10th day （ P 〉 0.05 ）. The recurrence rate of treatment group was lower than that of the control group （9.30% vs 27.91%, P 〈 0. 05 ）. Conclusion Both Live Preparation of Lactobacillus and Clolrimazole Suppositories are effective in treatment of vulvovaginal candidiasis, and can reduce the recurrence rate.