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脂联素基因启动子区多态位点与罗格列酮治疗2型糖尿病疗效的相关性 被引量：3

Effect of promoter variants in the ADIPOQ gene on the response to rosiglitazone in patients with type 2 diabetes mellitus
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摘要 目的研究编码脂联素的ADIPOQ基因启动子区单核苷酸多态性rs266729及rs16861194位点与罗格列酮治疗2型糖尿病疗效的相关性。方法选取103例新诊断的2型糖尿病患者,予罗格列酮口服48周,检测治疗前后与糖脂代谢相关的临床指标,并对患者进行rs266729及rs16861194位点基因分型。结果 rs266729位点少数等位基因(G)频率为22.0%(40/182),CC基因携带者56例,CG基因携带者30例,GG基因携带者5例;rs16861194位点少数等位基因(G)频率为15.2%(28/184),AA基因携带者66例,AG基因携带者24例,GG基因携带者2例。治疗后在rs16861194位点AG+GG基因携带者的空腹胰岛素水平(FIns)和稳态模型胰岛素抵抗指数(HOMA-IR)显著高于AA基因携带者(P值分别=0.0069和0.0104)。多元逐步回归分析显示,rs16861194位点(标准偏回归系数=2.01,P=0.0075)、治疗前的HOMA-IR(标准偏回归系数=0.37,P=0.0002)及体质指数(标准偏回归系数=0.19,P=0.0155)对罗格列酮治疗48周后的HOMA-IR具有独立预测作用。结论 ADIPOQ基因启动子区rs16861194位点与罗格列酮治疗2型糖尿病48周后胰岛素抵抗的改善有关。 Objective To evaluate the effect of two common promoter variants （rs266729 and rs16861194） in the ADIPOQ gene, which enGodes adiponectin, on the response to rosiglitazone monotherapy for type 2 diabetes mellitus （T2DM）. Methods Totally 103 newly diagnosed T2DM patients took orally rosiglitazone for 48 weeks. Olinical parameters associated with glycolipid metabolism were measured before and aftertreatment. Genotyping at rs266729 and rs16861194 was performed for all the patients. Results The minor allele frequency （MAF） for rs266729 was 22.0% （40/182）. There were 56, 30 and 5 carriers of CC, CG and GG genotypes, respectively. The MAF for rs16861194 was 15.2% （28/184）. There were 66, 24 and 2 carriers ofAA, AG and GG genotypes, respectively. After rosiglitazone monotherapy, the AG＋ GG genotype carriers for rs16861194 had significantly higher fasting serum insulin （Fins） and homeostasis model assessment for insulin resistance （HOMA-IR） as compared with AA genotype carriers （P = 0. 006 9 and 0.010 4）. Multivariate regression analysis revealed that rs16861194 （standard partial regression coefficient = 2.01, P = 0. 007 5）, HOMA-IR at baseline （standard partial regression coefficient = 0.37, P = 0. 000 2） and body mass index （standard partial regression coefficient = 0. 19, P = 0.015 5） were independent predictors for HOMA-IR after 48-week treatment with rosiglitazone. Conclusion rs16861494 at the promoter of ADIPOQ is associated with the improvement of insulinresistance after 48-week treatment with rosiglitazone in T2DM patients. （Shanghai Med J, 2012, 35, 32-36）
作者 徐靖 张蓉 胡承 王从容 秦雯 虞伟慧 项坤三 贾伟平
机构地区 上海市糖尿病研究所
出处 《上海医学》 CAS CSCD 北大核心 2012年第1期32-36,共5页 Shanghai Medical Journal
基金 上海市科学技术委员会重点实验室项目(08DZ2230200)及上海市科学技术委员会重大项目(08dj1400601)资助
关键词 药物基因组学 脂联素 2型糖尿病 Pharmacogenomics Adiponectin Type 2 diabetes mellitus
分类号 R587.1 [医药卫生—内分泌]
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参考文献16

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共引文献6

同被引文献43

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引证文献3

二级引证文献6

上海医学
2012年 第1期

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