丹参对瑞舒伐他汀在大鼠体内药代动力学的影响

Effect of Danshen on pharmacokinetics of Rosuvastatin in rats

目的研究丹参对瑞舒伐他汀在大鼠体内药代动力学影响。方法 12只雄性大鼠,体质量(230±15)g,随机分为2组:单用瑞舒伐他汀组(80 mg/kg)与瑞舒伐他汀合用丹参(400 mg/kg)组,每组6只,分别于给药前及给药后0.5、1、1.5、3、5、8、10、12、24 h时从眼眶静脉采血约0.3 ml,采用LC-MS测定血药浓度,比较两组间药代参数,利用SPSS12.0软件进行统计学处理。结果合用丹参后瑞舒伐他汀药代动力学参数Cmax、AUC0-t、AUC0-∞分别增加60.81%、88.00%和82.92%,而T1/2与CLz/F值分别降低了33.21%和21.51%。结论大鼠体内丹参可影响瑞舒伐他汀的药代动力学特性。

Objective To study the effect of Danshen on the pharmacokinetics of Rosuvastatin in rats.Methods Parallel control method was applied in this study.Twelve male rats weighing（230±15） g were evenly randomized into two groups： rosuvastatin（80 mg/kg） group and Rosuvastatin plus Danshen（400 mg/kg） group.Blood samples（0.3 ml each） were collected from the orbital vein at 0.5,1,1.5,3,5,8,10,12 and 24 h after drug administration.LC-MS was used to determine the plasma concentrations of Rosuvastatin.The pharmacokinetic parameters of the two groups were compared and statistical analysis was performed using SPSS12.0 software.Results When combined with Danshen,the Cmax,AUC0-t,and AUC0-∞ of Rosuvastatin were increased by 60.81%,88.00% and 82.92%,and T1/2 and CLz/F were reduced by 33.21% and 21.51%,respectively.Conclusion Danshen can affect the pharmacokinetic properties of Rosuvastatin in rats.