PLGA微粒中蛋白稳定性和完全释放的研究进展

Stability and complete release of protein from PLGA-based microparticles: an update

以PLGA为载体的蛋白药物微粒给药系统存在的最大的问题是蛋白稳定性和蛋白的完全释放。本文总结了增强蛋白药物稳定性和在体外释放期间促使蛋白完全释放的方法。蛋白药物完全释放的前提是保持蛋白稳定性。保持蛋白稳定性的方法之一是通过加入添加剂、对蛋白药物和聚合物进行修饰等避免蛋白在不利释放环境中聚集变性;另一个方法是避免不稳定环境的形成。

One of the most challenging issues in the delivery of therapeutic proteins from PLGA-based microparticles is the stability and complete release of the protein in its native form.This review summarizes the methods to promote the stability and in vitro release of protein from PLGA-based microparticles.Protein stability is the precondition of complete release.One way to keep protein stability is to use stabilizer or modify protein to avoid denaturation and aggregation;another way is to avoid the pro-instability environment.