大黄酸对内毒素激活小胶质细胞的影响

Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation

[目的]旨在观察大黄酸对小胶质细胞细胞株的作用。[方法]培养小胶质细胞细胞株,检测大黄酸对小胶质细胞活力及内毒素(LPS)诱导小胶质细胞一氧化氮(NO)产生的影响。[结果]大黄酸可以在不影响细胞活力的情况下抑制NO在激活小胶质细胞中的产生。[结论]大黄酸可以抑制LPS对小胶质细胞的激活。

[Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone, a metabolite from Salvia miltiorrhiza, may exert an anti-inflammatory effect in microglia. [Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide （NO） induced by LPS treatment in rat primary cultured microglia. [Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia. [Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it.