新型硅橡胶人工晶状体兔眼植入的生物相容性评价

Biocompatibility of new silicone intraocular lenses implanted into rabbit eyes

背景:软性人工晶状体的材料主要有硅凝胶、疏水性丙烯酸酯、亲水性丙烯酸酯和水凝胶等,但各材料优缺点不同,其长期生物学特性仍待临床检验。为改善白内障术后的视觉质量,提高人工晶状体的生物相容性及光学性能,进行新材料的开发是目前研究的热点。目的:评价自主研制的新型硅橡胶后房型人工晶状体兔眼植入半年的生物相容性。方法:选取20只新西兰白兔,均单眼行透明晶状体超声乳化吸除术联合人工晶状体植入,实验组(10眼)植入自主研制的硅橡胶(T-10)后房型人工晶状体,对照组(10眼)植入现已上市的硅凝胶后房型人工晶状体(EFC550)。结果与结论:植入后早期,两组兔眼均有较重的前房渗出,差异无显著性意义。两组兔眼后囊膜混浊程度差异无显著性意义。植入后90d及180d,实验组虹膜后粘连情况轻于对照组。可见新型硅橡胶人工晶状体色素层生物相容性优于硅凝胶人工晶状体,具有临床可应用性。

BACKGROUND： The soft intraocular lenses materials mainly include silica gel, hydrophobic acrylate, hydrophilic acrylate and hydrogel. The long-term biological characteristics of these materials are unclear because of their own advantages and disadvantages. Currently, the development of new materials is a hotspot research in order to improve the biocompatibility and optical property of intraocular lenses to achieve well visual quality of patients after cataract surgery. OBJECTIVE： To evaluate the biocompatibility of self-prepared new silicone intraocular lenses （IOLs） implanted into rabbit eyes for 6 months. METHODS： Twenty New Zealand albino rabbits undergoing phacoemulsification combined with intraocular lenses implantation in the left eye were divided into two groups randomly. The experimental group was implanted with T-10 IOLs. The rabbits implanted with EFC550 IOLs were taken as control. RESULTS AND CONCLUSION： Serious anterior chamber exudation was observed at later stage after operation in both groups and the difference in exudation between the two groups was not significant. The degrees of the posterior capsule opacification of the rabbit eyes in the experimental and control groups had no difference. The degree of the posterior synechia in the experimental group was lower than that in the control group at 90 and 180 days. The uveal biocompatibility of T-10 IOLs is better than that of the EFC550 IOLs. T-10 IOLs have a clinical applicability.