检测肿瘤坏死因子及可溶性肿瘤坏死因子受体Ⅰ在预测孕妇发生感染性早产的临床意义

Clinical significance of TNF-a and sTNFR Ⅰ in forecasting infectious associated preterm labor

目的研究肿瘤坏死因子(TNF-α)和可溶性肿瘤坏死因子受体Ⅰ(sTNFRⅠ)与孕妇出现感染性早产的关系。方法收集2009年12月-2011年5月在医院分娩的82例早产孕妇,分为早产非感染组45例和早产感染组37例,收集同期足月正常生产孕妇43例作为对照组,采用酶联免疫吸附法(ELISA)检测血清TNF-α、sTNFRI的水平。结果正常对照组的TNF-α为(2.1±0.3)pg/ml,早产非感染组的TNF-α为(2.4±1.2)pg/ml,差异无统计学意义;正常对照组的TNF-α和sTNFRⅡ分别为(2.1±0.3)、(3.3±0.6)pg/ml,早产感染组分别为(3.0±0.9)、(5.4±1.1)pg/ml,差异均有统计学意义(P<0.05);早产非感染组的TNF-α和sTNFRⅡ分别为(2.4±1.2)、(3.8±1.2)pg/ml,早产感染组为(3.0±0.9)、(5.4±1.1)pg/ml,差异均有统计学意义(P<0.05)。结论与TNF-α相比,sTNFRI在预测感染性早产方面的准确性更高。

OBJECTIVE To study the relation between tumor necrosis factor-α（TNF-α） and soluble tumor necrosis factor receptor I（sTNFR I） in forecasting the infectious associated preterm labor.METHODS From December 2009 to May 2011,82 cases of preterm labors were collected and separated into two groups： infectious associated preterm labor group 37 cases,and noninfectious preterm labor group 45 cases.Another 43 cases of healthy labors were collected as the normal control group at the same time.Serum levels of TNF-α and sTNFR I of all the cases were measured by enzyme linked immunosorbent assay（ELISA）.RESULTS TNF-α of normal control group and noninfectious preterm labor group had no statistical significance（2.1±0.3 pg/mL vs.2.4±1.2 pg/mL,P0.05）,but was higher in infectious associated preterm labor group（2.1±0.3 pg/mL vs.3.0±0.9 pg/mL,P0.05）.Compared with the normal controls,sTNFR I was significantly higher in noninfectious and infectious associated preterm labor groups（3.3±0.6 pg/mL vs 3.8±1.2 pg/mL,P0.05;3.3±0.6 pg/mL vs.5.4±1.1 pg/mL,P0.05）.Compared with noninfectious preterm labor group,TNF-α（2.4 ±1.2 pg/mL vs.3.0±0.9 pg/mL,P0.05） and sTNFR I（3.8±1.2 pg/mL vs.5.4±1.1 pg/mL,P0.05） in infectious associated preterm labor group were much higher.CONCLUSION Compared with TNF-α,sTNFR I might be a better factor in predicting infectious associated preterm labor.