鲍氏不动杆菌医院感染的耐药性调查

Antimicrobial resistance of Acinetobacter baumannii causing nosocomial infections

目的探讨鲍氏不动杆菌(ABA)医院感染现状及对抗菌药物的耐药性,为临床医师合理使用抗菌药物提供试验依据。方法 2006年1月-2010年12月从住院患者感染性标本中分离出225株ABA,细菌培养与鉴定严格按《全国临床检验操作规程》进行;药敏试验采用K-B法进行,依据CLSI最新折点判读结果。结果 ABA在呼吸道标本中检出率居第1位,达73.8%,ABA对常用抗菌药物产生了不同程度的耐药性,对碳青霉烯类抗菌药物亚胺培南、美罗培南耐药率分别为4.4%和5.8%,且发现ABA泛耐药菌株,检出率为1.3%。结论各级医院务必重视ABA耐药性的监测工作,预防与控制多药耐药ABA医院感染的发生暴发流行。

OBJECTIVE To investigate the infection status and antimicrobial resistance of Acinetobacter baumannii（ABA） causing nosocomial infections and provide experimental evidence for clinically reasonable application of antibiotics.METHODS According to National Guide to Clinical Laboratory Operation Procedures,bacterial culture and identification were performed for 225 strains of ABA isolated from infective specimens from the inpatients from Jan.2006 to Dec.2010.Drug susceptibility testing was performed by K-B methods.The test results were assessed according to CLSI breakpoints.RESULTS The isolation rate of ABA from respiratory tract was 73.8%,ranking the first.The susceptibility testing results indicated that ABA had been resistant to commonly used antibiotics of various degrees.The resistance rates to imipenem and meropenem were 4.4% and 5.8%,respectively.Detection rate of pan-resistant ABA strains was 1.3%.CONCLUSION Hospitals should attach importance to the monitoring of antimicrobial resistance of ABA,prevent and control the outbreaks and prevalence of nosocomial infections caused by multidrug-resistant ABA isolates.